EV-Pembro vs Chemo-IO: Choosing the Right Bladder Cancer Regimen

EV-Pembro vs Chemo-IO-Choosing the Right Bladder Cancer Regimen

Dr. Matt Galsky highlights how data from CREST and KEYNOTE trials support expanding immunotherapy use in bladder cancer, particularly in high-risk NMIBC and MIBC. He explains that EV pembrolizumab demonstrates strong, consistent benefits across endpoints, including pathologic response and event-free survival without compromising surgery outcomes. While EV-pembro is often preferred, he notes that patient selection remains critical, especially in variant histologies where alternative chemo-immunotherapy combinations may still be appropriate.

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